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Sebana Medical's SEBA™ innovation is a unique proprietary biologic delivery technology based on biodegradable Matrix Microparticles into which the active substance is embedded. It is possible to administer SEBA™ onto any quantity of fat tissue and control the release precisely at any desired rate, safely and cost-effectively for preventing fat resorption.

SEBA™ is an advanced proprietary technology, based on Matrix Microparticles containing active substances, enables precise and controlled release of the therapeutic agents over extended periods. With low systemic absorption and minimal adverse events, this technology effectively targets fat cells for soft tissue augmentation. Developed by Sebana Medical's Biomaterial Research Group in Nazareth, Israel, the technology is fully owned and patented by the company.


Sebana Medical has demonstrated that local slow release of the active substance in fat grafts (i) stimulates new blood vessel formation, (ii) suppresses the inflammatory response and (iii) block apoptosis of fat cells. The active substance is a glycoprotein hormone which regulates the red blood cell mass and is well-known and safe therapeutic molecule that was originally approved by the FDA as a biologic drug for treating anemia in patients with chronic kidney disease and for the treatment of anemia associated with cancer chemotherapy. 


SEBA™ Matrix is formed in an aqueous solution by the polymerization of proprietary matrix with the active substance, using a proprietary technique named sol-gel process. The resulting matrix is porous at the nanoscale and contains a varying number of OH groups and water. By changing the manufacturing process parameters, it is possible to vary the number of the OH groups and specific surface area (from a dense matrix to highly porous), both having an influence on the biodegradation rate of the matrix. When the matrix comes into contact with body fluids, the matrix is slowly dissolved. The dissolution of the matrix takes place mainly through an erosion mechanism. The biodegradation process does not change the pH within the matrix nor in the surrounding tissue in contrast to most commonly used alternative drug delivery matrices.


For fat transfer, fat tissue is removed from other parts of the patient’s body, usually thighs, belly, and buttocks by liposuction. The fat is then processed into liquid and reinjected back into the desired area. SEBA™ is intended for being mixed with the harvested fat prior grafting. After fat is being grafted with SEBA™, the active substance is slowly delivered over an enough period to protect the fat cells from being resorbed. The product labelling instructs the use of SEBA™ by plastic surgeons as an adjunct to, and not a substitute for, fat grafting treatment in the clinic. Since the active substance is slowly released in the fat grafts, treatment with SEBA™ is applied only one time (during the procedure), as a single treatment with no need for additional treatments.


SEBA™ technology can be applied to an unlimited number of fat transfer indications. The PLGA Matrix is suitable for the delivery of EPO molecules at any concentration and on any quantity of injected fat tissue. SEBA™ is designed to be mixed with the harvested fat tissue before reinjection into the desired area for soft tissue augmentation and can be used for various periods of release (30 days to 6 months). Although mainly focused on the active substance slow-delivery for a therapeutic solution to fat grafting in wrinkle removal, SEBA™ technology can be also used in other fat transfer indications such as in fat grafting for facial asymmetry, hand rejuvenation, HIV-drug related lipodystrophy, breast reconstruction, breast augmentation, buttock augmentation and penile enlargement.


SEBA™ is a unique product which has no competitors. Since SEBA™ is easy-to-use by plastic surgeons, SEBA™ will be the ultimate solution for preventing fat resorption. SEBA™ revolutionizes the fat grafting market and encourages plastic surgeons to use natural fillers over the currently existing expensive, non-lasting and unsafe synthetic fillers. Sebana Medical breakthrough science using slowly delivery on fat cells with SEBA™ technology is novel and a next generation innovation which can safely and dramatically promote the fat grafting technique.

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